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Article

Should tissue structure suppress or amplify selection to minimize cancer risk?

Biology direct - 23 Aug 2016

Hindersin Laura, Werner Benjamin, Dingli David, Traulsen Arne

Abstract excerpt

BACKGROUND: It has been frequently argued that tissues evolved to suppress the accumulation of growth enhancing cancer inducing mutations. A prominent example is the hierarchical structure of tissues with high cell turnover, where a small number of tissue specific stem cells produces a large number of specialized progeny during multiple differentiation steps. Another well known mechanism is the spatial...

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Identifiers

PMID: 27549612
DOI: 10.1186/s13062-016-0140-7
PMCID: PMC4994303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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