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Article

Does cancer solve an optimization problem?

Cell cycle (Georgetown, Tex.) - 1 Jul 2004

Komarova Natalia

Abstract excerpt

Many cancers are characterized by a high degree of aneuploidy, which is believed to be a result of chromosomal instability (CIN). The precise role of CIN in cancer is still the matter of a heated debate. We present a quantitative framework for examining the selection pressures acting on populations of cells and weigh the "pluses" and "minuses" of CIN from the point of view of a selfish cell. We calculate the...

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Share to Aneuploidy
Share to Carcinogens, Environmental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

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Share to Gene Expression Regulation, Neoplastic

Share to Genes, Tumor Suppressor

Share to Neoplasms

Source

Identifiers

PMID: 15190212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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