Article

Fanconi Anemia as a Window into Premalignant Field Cancerization of the Oral Mucosa

2026-06-15

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) evolves through stepwise clonal expansion within genetically altered mucosa fields, yet actionable biomarkers remain undefined. Leveraging Fanconi anemia (FA), a cancer predisposition syndrome with extreme HNSCC risk due to defective DNA interstrand crosslink repair, we profiled premalignant changes in the oral cavity using noninvasive brush biopsies. Consistent with o...

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Literature Corpus work: 2eac8ef1-10d4-5b07-b4bf-02205e3ce46b
DOI: 10.64898/2026.06.13.26354719

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