Article

Sex Steroid Hormone Signaling Tunes Metabolic and Neuronal Programs in Human Cortical Development

2026-05-19

Abstract excerpt

Autism spectrum disorder (ASD) exhibits a profound male biased sex ratio. While numerous genes have been implicated in ASD, the functional basis of this sex difference is unclear. One enticing hypothesis is genome-wide transcriptional regulation through estrogens and androgens. While hormone-mediated transcription is well-studied in reproductive tissues, its role in cortical development is poorly defined. Thus, w...

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Literature Corpus work: 7ec6c4d7-857c-57fe-b93e-8af9cccbfaa0
DOI: 10.64898/2026.05.16.725519

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