Article

HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity

2025-06-16

Abstract excerpt

In this study, we investigated the effects of HLA-DQB1*03:01 on the onset age of type-1 narcolepsy. We pooled data from 5,339 cases from China, Europe, Korea, Japan, and the United States to conduct the first transethnic study on age of onset (OA). GWAS was used to detect the associated genes. HLA alleles were imputed by HIBAG. Three datasets (DGN, CHINA, and CAUC) were used for TCR analyses. Chinese patients were...

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Literature Corpus work: 88af1ab2-af85-52f0-a183-75831a8ab936
DOI: 10.1101/2025.06.14.25328971

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