Article
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.
Nature genetics - 1 Sept 2010
Hor Hyun, Kutalik Zoltán, Dauvilliers Yves, Valsesia Armand, Lammers Gert J, Donjacour Claire E H M, Iranzo Alex, Santamaria Joan, Peraita Adrados Rosa, Vicario José L, Overeem Sebastiaan, Arnulf Isabelle, Theodorou Ioannis, Jennum Poul, Knudsen Stine, Bassetti Claudio, Mathis Johannes, Lecendreux Michel, Mayer Geert, Geisler Peter, Benetó Antonio, Petit Brice, Pfister Corinne, Bürki Julie Vienne, Didelot Gérard, Billiard Michel, Ercilla Guadalupe, Verduijn Willem, Claas Frans H J, Vollenweider Peter, Vollenwider Peter, Waeber Gerard, Waterworth Dawn M, Mooser Vincent, Heinzer Raphaël, Beckmann Jacques S, Bergmann Sven, Tafti Mehdi
Abstract excerpt
Narcolepsy is a rare sleep disorder with the strongest human leukocyte antigen (HLA) association ever reported. Since the associated HLA-DRB1*1501-DQB1*0602 haplotype is common in the general population (15-25%), it has been suggested that it is almost necessary but not sufficient for developing narcolepsy. To further define the genetic basis of narcolepsy risk, we performed a genome-wide association study (GWAS)...
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