Article
New susceptibility variants to narcolepsy identified in HLA class II region.
Human molecular genetics - 1 Feb 2015
Miyagawa Taku, Toyoda Hiromi, Hirataka Akane, Kanbayashi Takashi, Imanishi Aya, Sagawa Yohei, Kotorii Nozomu, Kotorii Tatayu, Hashizume Yuji, Ogi Kimihiro, Hiejima Hiroshi, Kamei Yuichi, Hida Akiko, Miyamoto Masayuki, Imai Makoto, Fujimura Yota, Tamura Yoshiyuki, Ikegami Azusa, Wada Yamato, Moriya Shunpei, Furuya Hirokazu, Kato Mitsuhiro, Omata Naoto, Kojima Hiroto, Kashiwase Koichi, Saji Hiroh, Khor Seik-Soon, Yamasaki Maria, Wada Yuji, Ishigooka Jun, Kuroda Kenji, Kume Kazuhiko, Chiba Shigeru, Yamada Naoto, Okawa Masako, Hirata Koichi, Uchimura Naohisa, Shimizu Tetsuo, Inoue Yuichi, Honda Yutaka, Mishima Kazuo, Honda Makoto, Tokunaga Katsushi
Abstract excerpt
Narcolepsy, a sleep disorder characterized by excessive daytime sleepiness, cataplexy and rapid eye movement sleep abnormalities, is tightly associated with human leukocyte antigen HLA-DQB1*06:02. DQB1*06:02 is common in the general population (10-30%); therefore, additional genetic factors are needed for the development of narcolepsy. In the present study, HLA-DQB1 in 664 Japanese narcoleptic subjects and 3131...
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