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Article

Homozygous HLA-DQB1*06:02 combined with T-cell receptor alpha polymorphism results in narcolepsy onset - A familial case report.

International journal of immunogenetics - 1 Jun 2024

Jervis Steven, Payton Antony, Verma Arpana, Thomasson Rachel, Poulton Kay

Abstract excerpt

Narcolepsy is a life-long neurological disorder with well-established genetic risk factors. Human leukocyte antigen-DQB1*06:02 remains the strongest genetic predeterminant; however, polymorphisms in genes encoding the T-cell receptor alpha chain are also strongly linked. This case report shows the inheritance pathway of these genetic markers contributing to narcolepsy onset in a 17-year-old female.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DQ beta-Chains

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Share to Polymorphism, Genetic

Share to Receptors, Antigen, T-Cell, alpha-beta

Source

Identifiers

PMID: 38462594
DOI: 10.1111/iji.12666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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