Article
DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe.
Sleep - 1 Jan 2014
Tafti Mehdi, Hor Hyun, Dauvilliers Yves, Lammers Gert J, Overeem Sebastiaan, Mayer Geert, Javidi Sirous, Iranzo Alex, Santamaria Joan, Peraita-Adrados Rosa, Vicario José L, Arnulf Isabelle, Plazzi Giuseppe, Bayard Sophie, Poli Francesca, Pizza Fabio, Geisler Peter, Wierzbicka Aleksandra, Bassetti Claudio L, Mathis Johannes, Lecendreux Michel, Donjacour Claire E H M, van der Heide Astrid, Heinzer Raphaël, Haba-Rubio José, Feketeova Eva, Högl Birgit, Frauscher Birgit, Benetó Antonio, Khatami Ramin, Cañellas Francesca, Pfister Corinne, Scholz Sabine, Billiard Michel, Baumann Christian R, Ercilla Guadalupe, Verduijn Willem, Claas Frans H J, Dubois Valérie, Nowak Jacek, Eberhard Hans-Peter, Pradervand Sylvain, Hor Charlotte N, Testi Manuela, Tiercy Jean-Marie, Kutalik Zoltán
Abstract excerpt
STUDY OBJECTIVE: Prior research has identified five common genetic variants associated with narcolepsy with cataplexy in Caucasian patients. To replicate and/or extend these findings, we have tested HLA-DQB1, the previously identified 5 variants, and 10 other potential variants in a large European sample of narcolepsy with cataplexy subjects. DESIGN: Retrospective case-control study. SETTING: A recent study...
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