Article
HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity.
Proceedings of the National Academy of Sciences of the United States of America - 16 Dec 2025
Zhang Lisan, Cai Shuo, Teng Ashton, Lin Ling, Han Fang, Yan Han, Hong Seung-Chul, Pizza Fabio, Plazzi Giuseppe, Morandi Luca, Stefani Ambra, Högl Birgit, Lecendreux Michel, Bourgin Patrice, Arnulf Isabelle, Knudsen-Heier Stine, Kanbayashi Takashi, Huang Yu-Shu, Jennum Poul, Sonka Karel, Nevsimalova Sona, Honda Makoto, Coelho Fernando Morgadinho, Pelin Zerrin, Ferini-Strambi Luigi, Miyagawa Taku, Khor Seik-Soon, Tokunaga Katsushi, Liu Wanlu, Mignot Emmanuel J
Abstract excerpt
Type 1 narcolepsy (T1N), an autoimmune disease associated with a disruption of hypocretin/orexin neurons, has conserved genetic effects transcending cultures and ethnicities. We pooled data from 5,339 cases from China, Europe, Korea, Japan, and the United States to conduct the first transethnic genome-wide association study (GWAS) on age of onset. Only one strong GWAS significant effect was observed across all...
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