Article
DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans.
Human immunology - 1 Jan 2007
Hong Seung-Chul, Lin Ling, Lo Betty, Jeong Jong-Hyun, Shin Yoon-Kyung, Kim Su-Yeon, Kweon Yongsil, Zhang Jing, Einen Mali, Smith Anajane, Hansen John, Grumet F Carl, Mignot Emmanuel
Abstract excerpt
The association of narcolepsy with HLA-DQB1*0602 is established in Japanese, African-Americans, European, and North American Caucasians. We examined DRB1, DRB3, DRB4, DRB5, DQA1, and DQB1 in 163 patients with centrally mediated daytime sleepiness (100 with narcolepsy) and 211 Korean controls. In this population, the DQB1*0602 association was always evident in the context of the DRB1*1501-DQA1*0102-DQB1*0602...
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