Article
Metabolic stability of mRNA in yeast--a potential target for modulating productivity?
Trends in biotechnology - 1 Nov 1994
Raué H A
Abstract excerpt
Attempts to improve the production of (heterologous) proteins in yeast cells have, to date, focused almost exclusively on increasing the transcriptional yield of the heterologous gene by raising the number of gene copies per cell, and/or putting the gene under the control of a strong homologous promoter. However, the cellular level of translatable mRNA is a function of the rate at which it is produced and the...
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