Article

Development of esterase-resistant and highly active ghrelin analogs via thiol-ene click chemistry

2022-06-30

Abstract excerpt

The orexigenic peptide ghrelin exerts important functions in energy metabolism and cellular homeostasis by activating the growth hormone secretagogue receptor type 1a (GHSR1a), and thus has therapeutic potential to treat certain diseases. Native ghrelin carries an essential O -fatty acyl moiety at the side-chain of its third Ser residue; however, this posttranslational modification is susceptible to hydrolysis by...

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Literature Corpus work: 8891c8bc-88d7-5507-8849-8a4747e6caa7
DOI: 10.1101/2022.06.29.498187

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