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Article

Development of ghrelin transgenic mice for elucidation of clinical implication of ghrelin.

Endocrine journal - 1 Jan 2017

Aotani Daisuke, Ariyasu Hiroyuki, Shimazu-Kuwahara Satoko, Shimizu Yoshiyuki, Nomura Hidenari, Murofushi Yoshiteru, Kaneko Kentaro, Izumi Ryota, Matsubara Masaki, Kanda Hajime, Noguchi Michio, Tanaka Tomohiro, Kusakabe Toru, Miyazawa Takashi, Nakao Kazuwa

Abstract excerpt

To elucidate the clinical implication of ghrelin, we have been trying to generate variable models of transgenic (Tg) mice overexpressing ghrelin. We generated Tg mice overexpressing des-acyl ghrelin in a wide variety of tissues under the control of β-actin promoter. While plasma des-acyl ghrelin level in the Tg mice was 44-fold greater than that of control mice, there was no differences in the plasma ghrelin...

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PMID: 28652541
DOI: 10.1507/endocrj.64.S31

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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