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Article

Systematic Design of Trypsin Cleavage Site Mutated Exendin4-Cysteine 1, an Orally Bioavailable Glucagon-Like Peptide-1 Receptor Agonist.

International journal of molecular sciences - 8 Mar 2017

Sai Wenbo, Tian Hong, Yang Kangmin, Tang Daoqi, Bao Jinxiao, Ge Yang, Song Xiaoda, Zhang Yu, Luo Cheng, Gao Xiangdong, Yao Wenbing

Abstract excerpt

Exendin-4 is a strong therapeutic candidate for the treatment of metabolic syndrome. Related receptor agonist drugs have been on the market since 2005. However, technical limitations and the pain caused by subcutaneous injection have severely limited patient compliance. The goal of the study is to investigate a biologically active exendin-4 analog could be administered orally. Using intraperitoneal glucose...

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Source

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Identifiers

PMID: 28282854
DOI: 10.3390/ijms18030578
PMCID: PMC5372594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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