Article

Amelioration of the Pharmacokinetics and Tissue Distribution of Flurbiprofen Axetil by Glycyrrhetinic Acid Derivatives for Enhanced Safety and Efficacy

2026-03-16

Abstract excerpt

Flurbiprofen axetil, an ester prodrug of flurbiprofen, undergoes premature hydrolysis in the gastrointestinal tract, causing mucosal injury and limiting its oral application. This study re-identified carboxylesterase 2 (CES2) as the primary enzyme responsible for this hydrolysis. Using glycyrrhetinic acid derivative GA13 as a selective CES2 inhibitor, we evaluated its effects on flurbiprofen pharmacokinetics, tiss...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 86869a5d-467f-520e-875e-e66cf7b4ac75
DOI: 10.22541/au.177366304.43880019/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Amelioration of the Pharmacokinetics and Tissue Distribution of Flurbiprofen Axetil by Glycyrrhetinic Acid Derivatives for Enhanced Safety and EfficacyDOI 10.22541/au.177366304.43880019/v1Read

Human absorption, distribution, metabolism, excretion, and reaction phenotyping of ervogastat (PF-06865571), a diacylglycerol O-acyltransferase 2 inhibitor.Semantic proximity Read

Development of SGLT1 and SGLT2 inhibitors.Semantic proximity Read

Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout miceSemantic proximity Read

Interventions with Potential to Mitigate Injection Site Reactions Following Subcutaneous Elamipretide Administration: A Phase 1, Crossover StudySemantic proximity Read

Pharmacological Characterization of SDX-7320/Evexomostat: a Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-Tumor and Anti-Metastatic ActivitySemantic proximity Read

Interventions with Potential to Mitigate Injection Site Reactions Following Subcutaneous Elamipretide Administration: A Phase 1, Crossover StudySemantic proximity Read

The efficacy and safety of Acetaminophen for pain reliefSemantic proximity Read

The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers.Semantic proximity Read

Parenteral Ready-to-Use Fixed-Dose Combinations of NSAIDs for Multimodal Analgesia – An overview of approved products and challengesSemantic proximity Read

Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans.Semantic proximity Read

Development Analysis and Strategic Insights from a 505(b)(2) Reformulation Product: EnzalutamideSemantic proximity Read

Investigation on modulation of human P-gp by multiple doses of Radix Astragali extract granules using fexofenadine as a phenotyping probe.Semantic proximity Read