Article

Allele-specific correction of ATAD3A pathogenic variants via template-free CRISPR-Cas9 editing and gene conversion

2025-10-24

Abstract excerpt

Gene conversion is a specific form of homologous recombination (HR), involving the unidirectional transfer of genetic information from one genomic locus to another. CRISPR-Cas9-directed double strand breaks (DSBs) induce both interallelic and interlocus gene conversion in early human embryos and somatic cells, suggesting its potential for correcting pathogenic mutations. However, the key features in mitotic gene c...

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Literature Corpus work: 888b15a7-0a6e-5e2d-9765-533c8d1409a3
DOI: 10.1101/2025.10.23.684255

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