Article

Interrogating the Mechanisms of Cas9-mediated Allele Conversion

2026-02-17

Abstract excerpt

Allele conversion describes a process where a heterozygous variant is made homozygous. Recently, it has been shown that allele conversion can be triggered by DNA damage at the heterozygous site. This process has the potential to repair pathogenic heterozygous mutations; however, the efficiency is low. Here, we endeavoured to understand the mechanism underlying allele conversion, ultimately to raise allele conversi...

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Literature Corpus work: 10852b12-0798-596f-b835-fc4e9d00be19
DOI: 10.64898/2026.02.17.705987

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