Article

PTBP1 promotes cardiac hypertrophy and diastolic dysfunction by modulating alternative splicing

2020-07-01

Abstract excerpt

Alternative splicing (AS) plays a major role in the generation of transcript diversity. In the heart, roles have been described for some AS variants and individual regulatory RNA binding proteins (RBPs); however, the global impact and regulation of AS patterns in cardiac pathophysiology is poorly understood. Here, we studied the AS profiles in heart disease, their relationship with heart development and the regula...

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Literature Corpus work: 8884a1ce-0d4a-57fb-9db1-6ab0764855c2
DOI: 10.1101/2020.06.30.171983

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