Article

In heart failure reactivation of RNA-binding proteins drives the transcriptome into a fetal state

2021-05-01

Abstract excerpt

Transcriptome-wide expression changes occur during heart failure, including reactivation of fetal-specific isoforms. However, the underlying molecular mechanisms and the extent to which a fetal gene program switch occurs remains unclear. Limitations hindering transcriptome-wide analyses of alternative splicing differences (i.e. isoform switching) in cardiovascular system (CVS) tissues between fetal and adult (heal...

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Literature Corpus work: 1f7e3c7c-2ed4-5a24-b77f-14072897df29
DOI: 10.1101/2021.04.30.442191

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