Article

Loss-of-function tolerance of enhancers in the human genome

2019-04-13

Abstract excerpt

Previous studies have surveyed the potential impact of loss-of-function (LoF) variants and identified LoF-tolerant protein-coding genes. However, the tolerance of human genomes to losing enhancers has not yet been evaluated. Here we present the catalog of LoF-tolerant enhancers using structural variants from whole-genome sequences. Using a conservative approach, we estimate that each individual human genome posses...

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Literature Corpus work: b063ae06-00e9-5913-90d3-681ce8b8b292
DOI: 10.1101/608257

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