Article

The STAT Signaling Pathway in HIV-1 Infection: Roles and Dysregulation

2025-08-28

Abstract excerpt

The STAT (Signal Transducer and Activator of Transcription) signaling pathway plays a central role in immune regulation by mediating cytokine responses and orchestrating both innate and adaptive immunity. Although CD4+ T cell depletion is the main driver of HIV-1–induced immunodeficiency, the virus also exerts a significant and often underestimated impact by disrupting the function of STAT family members, thereby...

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Literature Corpus work: 885781b1-9620-55af-a0b6-8ec78a46e070
DOI: 10.20944/preprints202508.2068.v1

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