Article

Dietary Monoterpenoids As a New Class of Allosteric Human Aryl Hydrocarbon Receptor Antagonists

2020-12-01

Abstract excerpt

<h4>ABSTRACT</h4> Carvones, the constituents of essential oils of dill, caraway, and spearmint, were reported to antagonize the human aryl hydrocarbon receptor (AhR); however, the exact molecular mechanism remains elusive. We show that carvones are non-competitive allosteric antagonists of the AhR that inhibit the induction of AhR target genes in a ligand-selective and cell type-specific manner. Carvones do not d...

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Literature Corpus work: 883c8f96-d2dc-5d4f-8c1a-694c9755e67a
DOI: 10.1101/2020.11.30.404178

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