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Resveratrol and 3,3’-diindolylmethane differentially regulate aryl hydrocarbon receptor and estrogen receptor alpha to modulate diverse signalling pathways in MCF-7 human breast cancer cells

2023-08-18

Abstract excerpt

<h4>Background: </h4> Inhibitory crosstalk between estrogen receptor alpha (ERα) and aryl hydrocarbon receptor (AHR) regulates 17β-estradiol (E2)-dependent breast cancer cell signalling. ERα and AHR are ligand activated transcription factors that mediate the actions of E2 and pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), respectively. Like ERα, AHR binds many dietary compounds, including resveratr...

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Literature Corpus work
12af16a0-e371-5546-8433-fb547e02401d
DOI
10.21203/rs.3.rs-3255817/v1
Open publication

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Resveratrol and 3,3’-diindolylmethane differentially regulate aryl hydrocarbon receptor and estrogen receptor alpha to modulate diverse signalling pathways in MCF-7 human breast cancer cellsDOI 10.21203/rs.3.rs-3255817/v1
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