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Article

Design, Synthesis, and Biological Evaluation of Levoglucosenone‐Derived Ras Activation Inhibitors

18 Feb 2009

Abstract excerpt

A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone-derived scaffold with aromatic moieties. Some members of the panel show in vitro inhibitory activity toward the nucleotide exchange process on Ras and are toxic to some human cancer cell lines.

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PMID: 19226500
DOI: 10.1002/cmdc.200800416

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