Article

Crim1 involves in mechanical overloading-caused extracellular matrix degradation and type H vessels formation through the FAK-MAPK signaling pathway in osteoarthritis

2023-07-03

Abstract excerpt

<h4>Background: </h4> Osteoarthritis (OA) is the most common bone disease with the high disability rate. Mechanical overloading is vital for the pathogenesis of OA, and the precise mechanisms by which mechanical overloading regulates chondrocytes remain largely unclear. Methods The expression of Crysteine-Rich Transmembrane BMP Regulator-1 (Crim1) was assessed in vitro , in mice with experimental OA, and in carti...

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Literature Corpus work: 8839bf6b-7cd4-52dd-8f04-2d8166569795
DOI: 10.21203/rs.3.rs-3117786/v1

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