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Article

Homologous recombination deficiency status-based classification of high-grade serous ovarian carcinoma.

Scientific reports - 17 Feb 2020

Takaya Hisamitsu, Nakai Hidekatsu, Takamatsu Shiro, Mandai Masaki, Matsumura Noriomi

Abstract excerpt

Homologous recombination repair (HRR) pathway deficiency (HRD) is involved in the tumorigenesis and progression of high-grade serous ovarian carcinoma (HGSOC) as well as in the sensitivity to platinum chemotherapy drugs. In this study, we obtained data from The Cancer Genome Atlas (TCGA) on HGSOC and identified scores for the loss of heterozygosity, telomeric allelic imbalance, and large-scale state transitions,...

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Identifiers

PMID: 32066851
DOI: 10.1038/s41598-020-59671-3
PMCID: PMC7026096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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