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Altered Enhancer and Promoter Usage Leads to Differential Gene Expression in the Normal and Failed Human Heart

30 Sept 2020

Abstract excerpt

BACKGROUND: The failing heart is characterized by changes in gene expression. However, the regulatory regions of the genome that drive these gene expression changes have not been well defined in human hearts. METHODS: To define genome-wide enhancer and promoter use in heart failure, cap analysis of gene expression sequencing was applied to 3 healthy and 4 failed human hearts to identify promoter and enhancer...

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PMID: 32993371
DOI: 10.1161/circheartfailure.120.006926

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