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Article

FAD-mutation of APP is associated with a loss of its synaptotrophic activity.

Neurobiology of disease - 1 Aug 2009

Seeger Gudrun, Gärtner Ulrich, Ueberham Uwe, Rohn Susanne, Arendt Thomas

Abstract excerpt

Alzheimer's disease (AD) is a chronic neurodegenerative disorder associated with extracellular accumulation of Abeta peptide that derives from the amyloid precursor protein (APP). While amyloidogenic processing of APP has received most attention, the physiological function of APP and the sequelae of potentially impaired APP function are less understood. APP is a transmembrane glycoprotein being widely expressed...

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Source

Identifiers

PMID: 19450683
DOI: 10.1016/j.nbd.2009.05.003

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FAD-mutation of APP is associated with a loss of its synaptotrophic activity.PMID 19450683Read ↗

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