Article

Gradual Compaction of the Central Spindle Decreases its Dynamicity as Revealed in PRC1 and EB1 Gene-Edited Human Cells

2020-07-09

Abstract excerpt

<h4>ABSTRACT</h4> During mitosis the spindle undergoes morphological and dynamic changes. It reorganizes at the onset of anaphase when the antiparallel bundler PRC1 accumulates and recruits central spindle proteins to the midzone. Little is known about how the dynamic properties of the central spindle change during its morphological changes in human cells. Using gene editing, we generated human cells that express...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 87ff7628-82a9-53a8-a92b-f37ea344aff6
DOI: 10.1101/2020.07.09.195347

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gradual Compaction of the Central Spindle Decreases its Dynamicity as Revealed in PRC1 and EB1 Gene-Edited Human CellsDOI 10.1101/2020.07.09.195347Read

High-resolution imaging reveals how the spindle midzone impacts chromosome movementSemantic proximity Read

Mitotic chromosome alignment is required for proper nuclear envelope reassemblySemantic proximity Read

An anaphase surveillance mechanism prevents micronuclei formation from mitotic errorsSemantic proximity Read

Cell confinement initiates a delayed but heritable loss of chromosomesSemantic proximity Read

Misaligned chromosomes that satisfy the spindle assembly checkpoint are a strong predictor of micronuclei formation in dividing cancer cellsSemantic proximity Read

Non-Random Mis-Segregation of Human ChromosomesSemantic proximity Read

PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone.Semantic proximity Read

Measuring and modeling the dynamics of mitotic error correctionSemantic proximity Read

Cyclin A/Cdk1 promotes chromosome alignment and timely mitotic progressionSemantic proximity Read

The RZZ complex integrates spindle checkpoint maintenance with dynamic expansion of unattached kinetochoresSemantic proximity Read

Regulation of midzone microtubule dynamics and abscission in human cells by CAMSAP2 and Kif2aSemantic proximity Read

Cohesin loss eliminates all loop domains, leading to links among superenhancers and downregulation of nearby genesSemantic proximity Read