Article

Hunting for microsatellite instability in long-read data with Owl

2026-03-10

Abstract excerpt

Microsatellite instability (MSI) is a key biomarker of mismatch repair deficiency and response to immunotherapy, yet most existing genomic detection methods are optimized for short-read sequencing and rely on small panels of homopolymer markers, limiting the ability to characterize genome-wide and motif-specific patterns of instability. Here we present Owl, a bioinformatic tool for quantifying MSI from long-read (...

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Literature Corpus work: 87e5eed1-cad4-50c0-85c6-58ed9d8ff0c5
DOI: 10.64898/2026.03.08.708905

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