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Article

MSIanalyzer: Targeted Nanopore Sequencing Enables Single Nucleotide Resolution Analysis of Microsatellite Instability Diversity.

Journal of molecular biology - 1 Aug 2026

Zhai Ting, Cheong Ana, Laverty Daniel J, Nagel Zachary D

Abstract excerpt

We present MSIanalyzer, a targeted sequencing-based pipeline profiling microsatellite instability (MSI) at single-nucleotide repeat-unit resolution, with base-level annotation of non-repeat interruptions where identifiable. Using Oxford Nanopore sequencing of the five Bethesda panel loci, we characterized repeat-unit distributions across mismatch repair (MMR)-deficient and MMR-proficient cell lines and primary...

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PMID: 41999939
DOI: 10.1016/j.jmb.2026.169812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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