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Article

Multitasking guardian of mitochondrial quality: Parkin function and Parkinson's disease.

Translational neurodegeneration - 20 Jan 2021

Kamienieva Iryna, Duszyński Jerzy, Szczepanowska Joanna

Abstract excerpt

The familial form of Parkinson's disease (PD) is linked to mutations in specific genes. The mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases, because mitochondria are highly dynamic structures integrated with many cellular functions. Herein, we overview and discuss the role of the parkin...

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Identifiers

PMID: 33468256
DOI: 10.1186/s40035-020-00229-8
PMCID: PMC7816312

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