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Applications and explorations of CRISPR/Cas9 in CAR T-cell therapy

13 Dec 2019

Abstract excerpt

Chimeric antigen receptor(CAR) T-cell therapy has shown remarkable effects and promising prospects in patients with refractory or relapsed malignancies, pending further progress in the next-generation CAR T cells with more optimized structure, enhanced efficacy and reduced toxicities. The clustered regulatory interspaced short palindromic repeat/CRISPR-associated protein 9 (CRISPR/Cas9) technology holds immense...

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PMID: 31950135
DOI: 10.1093/bfgp/elz042

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