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5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma

18 Dec 2019

Abstract excerpt

PURPOSE: 5-Hydroxymethylcytosine (5-hmC) is an epigenetic marker of open chromatin and active gene expression. We profiled 5-hmC with Nano-hmC-Seal technology using 10 ng of plasma-derived cell-free DNA (cfDNA) in blood samples from patients with neuroblastoma to determine its utility as a biomarker. EXPERIMENTAL DESIGN: = 29) generated from 21 patients (20 high-risk and 1 intermediate-risk). Metastatic burden...

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PMID: 31852832
DOI: 10.1158/1078-0432.ccr-19-2829

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