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Article

Darwinian and demographic forces affecting human protein coding genes.

Genome research - 1 May 2009

Nielsen Rasmus, Hubisz Melissa J, Hellmann Ines, Torgerson Dara, Andrés Aida M, Albrechtsen Anders, Gutenkunst Ryan, Adams Mark D, Cargill Michele, Boyko Adam, Indap Amit, Bustamante Carlos D, Clark Andrew G

Abstract excerpt

Past demographic changes can produce distortions in patterns of genetic variation that can mimic the appearance of natural selection unless the demographic effects are explicitly removed. Here we fit a detailed model of human demography that incorporates divergence, migration, admixture, and changes in population size to directly sequenced data from 13,400 protein coding genes from 20 European-American and 19...

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Identifiers

PMID: 19279335
DOI: 10.1101/gr.088336.108
PMCID: PMC2675972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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