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Pharmacodynamic model of PARP1 inhibition and global sensitivity analyses can lead to cancer biomarker discovery

2023-02-10

Abstract excerpt

Pharmacodynamic models provide inroads to understanding key mechanisms of action and may significantly improve patient outcomes in cancer with improved ability to determine therapeutic benefit. Additionally, these models may also lead to insights into potential biomarkers that can be utilized for prediction in prognosis and therapeutic decisions. As an example of this potential, here we present an advanced computa...

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Literature Corpus work
b88ff4b4-acb9-577d-80fd-972a961bafef
DOI
10.1101/2023.02.08.527527
Open publication

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Pharmacodynamic model of PARP1 inhibition and global sensitivity analyses can lead to cancer biomarker discoveryDOI 10.1101/2023.02.08.527527
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