To breathe or not to breathe: Understanding how oxygen sensing contributes to age-related phenotypes.

Abstract excerpt

Aging is characterized by a progressive loss of tissue integrity and functionality due to disrupted homeostasis. Molecular oxygen is pivotal to maintain tissue functions, and aerobic species have evolved a sophisticated sensing system to ensure proper oxygen supply and demand. It is not surprising that aberrations in oxygen and oxygen-associated pathways subvert health and promote different aspects of aging. In...

Topics

• Cellular Senescence
• Longevity
• Oxygen
• Phenotype
• Reactive Oxygen Species