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NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth <i>Schistosoma mansoni</i>

2024-03-13

Abstract excerpt

Infection with the helminth Schistosoma mansoni can cause exacerbated morbidity and mortality via a pathogenic host CD4 T cell-mediated immune response directed against parasite egg antigens, with T helper (Th) 17 cells playing a major role in the development of severe granulomatous hepatic immunopathology. The role of inflammasomes in intensifying disease has been reported; however, neither the types of caspases...

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Literature Corpus work
9f7b3dab-8cdb-5c27-9d4b-8f2db0c183b1
DOI
10.1101/2024.03.11.584371
Open publication

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NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth <i>Schistosoma mansoni</i>DOI 10.1101/2024.03.11.584371
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