Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females

Abstract excerpt

Women represent about 80% of patients with autoimmune diseases. This may partly result from sex-based differences in T cell receptor (TCR) selection during thymocyte development, potentially influenced by hormones and the lower expression of the Autoimmune Regulator (AIRE) transcription factor in females. To investigate this, we analyzed sex-specific differences in TCR generation and selection. We examined TCR rep...

Topics

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• AIRE Protein
• Autoimmune Diseases
• Disease Susceptibility
• Gonadal Steroid Hormones
• Models, Immunological
• Positive Regulatory Domain I-Binding Factor 1
• Sex Factors
• Thymus Gland

Identifiers and source

Literature Corpus work

879355c1-edc9-52cb-ab7b-0da3a0907d26

DOI

10.1101/2025.01.21.633929