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Article

Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator

13 Apr 2016

Abstract excerpt

Male gender is protective against multiple sclerosis and other T-cell-mediated autoimmune diseases. This protection may be due, in part, to higher androgen levels in males. Androgen binds to the androgen receptor (AR) to regulate gene expression, but how androgen protects against autoimmunity is not well understood. Autoimmune regulator (Aire) prevents autoimmunity by promoting self-antigen expression in...

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Share to Adrenal Hormones and Disorders
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Share to T-cell and B-cell Immunology

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PMID: 27072778
DOI: 10.1038/ncomms11350

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