Article
Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases.
Nature communications - 22 Sept 2021
Fernandez Lahore Gonzalo, Förster Michael, Johannesson Martina, Sabatier Pierre, Lönnblom Erik, Aoun Mike, He Yibo, Nandakumar Kutty Selva, Zubarev Roman A, Holmdahl Rikard
Abstract excerpt
Complex autoimmune diseases are sexually dimorphic. An interplay between predisposing genetics and sex-related factors probably controls the sex discrepancy in the immune response, but the underlying mechanisms are unclear. Here we positionally identify a polymorphic estrogen receptor binding site that regulates Cd2 expression, leading to female-specific differences in T cell-dependent mouse models of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.