Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases

20 Mar 2016

Abstract excerpt

Autoimmune diseases affect 5% to 8% of the population, and females are more susceptible to these diseases than males. Here, we analyzed human thymic transcriptome and revealed sex-associated differences in the expression of tissue-specific antigens that are controlled by the autoimmune regulator (AIRE), a key factor in central tolerance. We hypothesized that the level of AIRE is linked to sexual dimorphism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Hormones and Disorders
Share to T-cell and B-cell Immunology
Share to Urticaria and Related Conditions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26999605
DOI: 10.1172/jci81894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseasesPMID 26999605Read ↗

AIRE: a missing link to explain female susceptibility to autoimmune diseases.Semantic proximity Read ↗

Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulatorSemantic proximity Read ↗

Aire in Autoimmunity.Semantic proximity Read ↗

AIRE expands: new roles in immune tolerance and beyond.Semantic proximity Read ↗

Update on Aire and thymic negative selection.Semantic proximity Read ↗

The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune DiseasesSemantic proximity Read ↗

Expression and function of the autoimmune regulator (Aire) gene in non-thymic tissueSemantic proximity Read ↗

The Thymic Orchestration Involving Aire, miRNAs, and Cell–Cell Interactions during the Induction of Central ToleranceSemantic proximity Read ↗

Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in femalesSemantic proximity Read ↗

The Autoimmune Regulator Prevents Premature Reproductive Senescence in Female Mice1Semantic proximity Read ↗

The role of Aire in clonal selectionSemantic proximity Read ↗

The role of AIRE in human autoimmune disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.