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Why women have more autoimmune diseases than men: An evolutionary perspective

15 Nov 2020

Abstract excerpt

Women have up to a fourfold increase in risk for autoimmune disease compared to men. Many explanations have been proposed, including sex hormones, the X chromosome, microchimerism, environmental factors, and the microbiome. However, the mechanism for this autoimmune sex bias remains obscure. In this manuscript, we evaluate the hypothesis that qualitative or quantitative differences in circulating antibodies may...

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PMID: 33767739
DOI: 10.1111/eva.13167

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