Article

Brr2 is a splicing fidelity factor

2018-06-22

Abstract excerpt

Many spliceosomal DExD/H box helicases act as fidelity factors during pre-mRNA splicing, promoting on-pathway interactions while simultaneously minimizing errors. Mutations linked to Retinitis Pigmentosa (RP), a form of heritable blindness, map to key domains of spliceosomal helicase Brr2 ( SNRNP200 in humans). Previous data show that such mutations negatively impact spliceosome activation, likely due to defects...

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Identifiers and source

Literature Corpus work: 878190ba-5a41-5ca0-92be-07d7d10b149c
DOI: 10.1101/354514

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