Article
Integrative omics analyses broaden treatment targets in human cancer.
Genome medicine - 27 Jul 2018
Sengupta Sohini, Sun Sam Q, Huang Kuan-Lin, Oh Clara, Bailey Matthew H, Varghese Rajees, Wyczalkowski Matthew A, Ning Jie, Tripathi Piyush, McMichael Joshua F, Johnson Kimberly J, Kandoth Cyriac, Welch John, Ma Cynthia, Wendl Michael C, Payne Samuel H, Fenyö David, Townsend Reid R, Dipersio John F, Chen Feng, Ding Li
Abstract excerpt
BACKGROUND: Although large-scale, next-generation sequencing (NGS) studies of cancers hold promise for enabling precision oncology, challenges remain in integrating NGS with clinically validated biomarkers. METHODS: To overcome such challenges, we utilized the Database of Evidence for Precision Oncology (DEPO) to link druggability to genomic, transcriptomic, and proteomic biomarkers. Using a pan-cancer cohort of...
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