The Role of Genetic and Epigenetic Regulation in Intestinal Fibrosis in Inflammatory Bowel Disease: A Descending Process or a Programmed Consequence?

doi:10.3390/genes14061167

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Article

The Role of Genetic and Epigenetic Regulation in Intestinal Fibrosis in Inflammatory Bowel Disease: A Descending Process or a Programmed Consequence?

Genes - 27 May 2023

Jarmakiewicz-Czaja Sara, Sokal Aneta, Ferenc Katarzyna, Motyka Elżbieta, Helma Kacper, Filip Rafał

Abstract excerpt

Inflammatory bowel diseases (IBDs) are a group of chronic diseases characterized by recurring periods of exacerbation and remission. Fibrosis of the intestine is one of the most common complications of IBD. Based on current analyses, it is evident that genetic factors and mechanisms, as well as epigenetic factors, play a role in the induction and progression of intestinal fibrosis in IBD. Key genetic factors and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37372347
DOI: 10.3390/genes14061167
PMCID: PMC10297896

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