Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics.

Cell death & disease - 8 Dec 2011

Nguyen D, Alavi M V, Kim K-Y, Kang T, Scott R T, Noh Y H, Lindsey J D, Wissinger B, Ellisman M H, Weinreb R N, Perkins G A, Ju W-K

Abstract excerpt

Glutamate excitotoxicity leads to fragmented mitochondria in neurodegenerative diseases, mediated by nitric oxide and S-nitrosylation of dynamin-related protein 1, a mitochondrial outer membrane fission protein. Optic atrophy gene 1 (OPA1) is an inner membrane protein important for mitochondrial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-2-Associated X Protein
Share to bcl-Associated Death Protein
Share to bcl-X Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to GTP Phosphohydrolases

Share to Optic Atrophy, Autosomal Dominant

Share to Receptors, N-Methyl-D-Aspartate

Share to Retinal Ganglion Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 22158479
DOI: 10.1038/cddis.2011.117
PMCID: PMC3252734

Genes

OPA1
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22158479-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics.PMID 22158479Read ↗

Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cellsSemantic proximity Read ↗

Optic neuropathies: the tip of the neurodegeneration icebergSemantic proximity Read ↗

Mitochondrial fission in apoptosis, neurodegeneration and aging.Semantic proximity Read ↗

Overexpression of Optic Atrophy Type 1 Protects Retinal Ganglion Cells and Upregulates Parkin Expression in Experimental GlaucomaSemantic proximity Read ↗

Dominant optic atrophy: updates on the pathophysiology and clinical manifestations of the optic atrophy 1 mutation.Semantic proximity Read ↗

Mitochondrial Ca2+ uptake correlates with the severity of the symptoms in autosomal dominant optic atrophy.Semantic proximity Read ↗

AKAP1 regulates mitochondrial and synaptic homeostasis to enable neuroprotection and repair in retinal ganglion cell degenerationSemantic proximity Read ↗

The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.Semantic proximity Read ↗

DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.Semantic proximity Read ↗

OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response.Semantic proximity Read ↗

Mitochondrial dynamics and disease, OPA1.Semantic proximity Read ↗

Mitochondrial optic neuropathies: how two genomes may kill the same cell type?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.