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Mitochondrial Fragmentation and Long Noncoding RNA MALAT1 in Diabetic Retinopathy

3 Jul 2025

Abstract excerpt

Mitochondria are dynamic in nature and depending on the energy demand they fuse and divide. This fusion-fission process is impaired in diabetic retinopathy and the promoter DNA of Mfn2, a fusion gene, is hypermethylated and its expression is downregulated. Long noncoding RNAs (RNAs with >200 nucleotides that do not encode proteins) can regulate gene expression by interacting with DNA, RNA, and proteins. Several...

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PMID: 40650203
DOI: 10.3390/ijms26136429

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