Article

MMP21 behaves as a fluid flow transported morphogen to impart laterality during development

2024-10-13

Abstract excerpt

Heterotaxy (HTX) is frequently caused by deleterious variants in the gene encoding Matrix metallopeptidase 21 (MMP21). However, the underlying pathomechanism has not been ascertained. In this study, we report on a novel HTX-associated MMP21 knockout allele in humans and investigate the peptidase’s role during laterality development using Xenopus embryos as animal model. The targeted inactivation of mmp21 in f0...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 875eb240-c7e4-5367-94c9-c5414d2a435e
DOI: 10.1101/2024.10.13.618030

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MMP21 behaves as a fluid flow transported morphogen to impart laterality during developmentDOI 10.1101/2024.10.13.618030Read

A Novel Nonsense MMP21 Variant Causes Dextrocardia and Congenital Heart Disease in a Han Chinese PatientSemantic proximity Read

Roles of the cilium-associated gene CCDC11 in left-right patterning and in laterality disorders in humans.Semantic proximity Read

A human laterality disorder associated with a homozygous WDR16 deletion.Semantic proximity Read

Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetrySemantic proximity Read

The genetic landscape of cardiovascular left-right patterning defects.Semantic proximity Read

Understanding laterality disorders and the left-right organizer: Insights from zebrafishSemantic proximity Read

Functional analysis of novel MMP21 gene compound heterozygous mutations in a prenatal case with heterotaxy.Semantic proximity Read

Acute knockdown of extracellular matrix protein Tinagl1 disrupts heart laterality and pronephric cilia in zebrafish embryonic developmentSemantic proximity Read

ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish.Semantic proximity Read

Genetic basis of human left–right asymmetry disordersSemantic proximity Read

Disorders of left-right asymmetry: heterotaxy and situs inversus.Semantic proximity Read

Wnt and Nodal asymmetries stratify mouse laterality phenotypes in the absence of node flow.Semantic proximity Read